LymphedemaV1, Main, Exploration, bibRecord, 002D30

Association Between Serotonin Transport Polymorphisms and Postdischarge Nausea and Vomiting in Women Following Breast Cancer Surgery

Identifieur interne : 002D30 ( Main/Exploration ); précédent : 002D29; suivant : 002D31

Association Between Serotonin Transport Polymorphisms and Postdischarge Nausea and Vomiting in Women Following Breast Cancer Surgery

Auteurs : Susan W. Wesmiller ; Catherine M. Bender ; Susan M. Sereika ; Gretchen Ahrendt ; Marguerite Bonaventura ; Dana H. Bovbjerg ; Yvette Conley

Source :

Oncology nursing forum [ 0190-535X ] ; 2014.

RBID : PMC:4023462

Abstract

Purpose/Objectives

To examine the association of the serotonin transport gene and postdischarge nausea and vomiting (PDNV) in women following breast cancer surgery.

Design

A cross-sectional study.

Setting

A comprehensive cancer center in Pittsburgh, PA.

Sample

80 post-menopausal women treated surgically for early-stage breast cancer.

Methods

Data were collected using standardized instruments after surgery but before the initiation of chemotherapy. Blood or saliva were used for DNA extraction and analyzed following standardized protocols. Data were analyzed using descriptive statistics and logistic regression.

Main Research Variables

Serotonin transport gene (SLC6A4), nausea, vomiting, pain, and anxiety.

Findings

Women who inherited the L_A/L_A genotypes were at greater risk for nausea and vomiting when compared to women who carried any other combination of genotypes. Twenty-one percent of women reported nausea and vomiting an average of one month following surgery and prior to initiation of adjuvant therapy. Those women who experienced PDNV reported significantly higher anxiety and pain scores.

Conclusions

Findings of this study suggest that variability in the genotypes of the serotonin transport gene may help to explain the variability in PDNV in women following breast cancer surgery and why 20%–30% of patients do not respond to antiemetic medications.

Implications for Nursing

Nurses need to be aware that women who do not experience postoperative nausea and vomiting following surgery for breast cancer continue to be at risk for PDNV long after they have been discharged from the hospital, and this frequently is accompanied by pain and anxiety.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4023462

DOI: 10.1188/14.ONF.195-202
PubMed: 24578078
PubMed Central: 4023462

Affiliations:

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<front><div type="abstract" xml:lang="en"><sec id="S1"><title>Purpose/Objectives</title>
<p id="P1">To examine the association of the serotonin transport gene and postdischarge nausea and vomiting (PDNV) in women following breast cancer surgery.</p>
</sec>
<sec id="S2"><title>Design</title>
<p id="P2">A cross-sectional study.</p>
</sec>
<sec id="S3"><title>Setting</title>
<p id="P3">A comprehensive cancer center in Pittsburgh, PA.</p>
</sec>
<sec id="S4"><title>Sample</title>
<p id="P4">80 post-menopausal women treated surgically for early-stage breast cancer.</p>
</sec>
<sec id="S5"><title>Methods</title>
<p id="P5">Data were collected using standardized instruments after surgery but before the initiation of chemotherapy. Blood or saliva were used for DNA extraction and analyzed following standardized protocols. Data were analyzed using descriptive statistics and logistic regression.</p>
</sec>
<sec id="S6"><title>Main Research Variables</title>
<p id="P6">Serotonin transport gene (<italic>SLC6A4</italic>
), nausea, vomiting, pain, and anxiety.</p>
</sec>
<sec id="S7"><title>Findings</title>
<p id="P7">Women who inherited the L<sub>A</sub>
/L<sub>A</sub>
 genotypes were at greater risk for nausea and vomiting when compared to women who carried any other combination of genotypes. Twenty-one percent of women reported nausea and vomiting an average of one month following surgery and prior to initiation of adjuvant therapy. Those women who experienced PDNV reported significantly higher anxiety and pain scores.</p>
</sec>
<sec id="S8"><title>Conclusions</title>
<p id="P8">Findings of this study suggest that variability in the genotypes of the serotonin transport gene may help to explain the variability in PDNV in women following breast cancer surgery and why 20%–30% of patients do not respond to antiemetic medications.</p>
</sec>
<sec id="S9"><title>Implications for Nursing</title>
<p id="P9">Nurses need to be aware that women who do not experience postoperative nausea and vomiting following surgery for breast cancer continue to be at risk for PDNV long after they have been discharged from the hospital, and this frequently is accompanied by pain and anxiety.</p>
</sec>
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<name sortKey="Bonaventura, Marguerite" sort="Bonaventura, Marguerite" uniqKey="Bonaventura M" first="Marguerite" last="Bonaventura">Marguerite Bonaventura</name>
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Association Between Serotonin Transport Polymorphisms and Postdischarge Nausea and Vomiting in Women Following Breast Cancer Surgery

Association Between Serotonin Transport Polymorphisms and Postdischarge Nausea and Vomiting in Women Following Breast Cancer Surgery

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Abstract

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